Article

Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms

2019-04-07

Abstract excerpt

Eukaryotic genes often generate a variety of RNA isoforms that can lead to functionally distinct protein variants. The synthesis and stability of RNA isoforms is however poorly characterized. The reason for this is that current methods to quantify RNA metabolism use ‘short-read’ sequencing that cannot detect RNA isoforms. Here we present nanopore sequencing-based Isoform Dynamics (nano-ID), a method that detects n...

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Literature Corpus work: 295e73f8-c810-5eee-a274-a95b53300073
DOI: 10.1101/601856

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