Article

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

2021-06-09

Abstract excerpt

<h4>SUMMARY</h4> The epitranscriptome plays a key regulatory role in cellular processes in health and disease, including ribosome biogenesis. Here, analysis of the human mitochondrial transcriptome shows that 2’- O -methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, modified by MRM1, MRM2, and MRM3. Ablation of MRM2 leads to a severe impairment of the oxidative phosphoryla...

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Literature Corpus work: 02c3cd1e-367b-578f-9a69-9b7023090ee9
DOI: 10.1101/2021.06.09.447755

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