Article

Transcriptome-wide RNA accessibility mapping reveals structured RNA elements and pervasive conformational rearrangements under stress

2025-06-05

Abstract excerpt

<h4>ABSTRACT</h4> RNA structure plays a central role in post-transcriptional gene regulation, modulating RNA stability, translation, and interactions with RNA-binding proteins (RBPs). However, capturing RNA conformations at scale remains challenging. Here, we introduce DMS-TRAM-seq (Dimethyl Sulfate–Transcriptome-wide RNA Accessibility Mapping by sequencing), which probes RNA structure across nearly the entire tr...

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Literature Corpus work: b73eefea-7542-55c6-92d7-141b9ffbd95e
DOI: 10.1101/2025.06.05.658101

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