Article

A kinetic dichotomy between mitochondrial and nuclear gene expression drives OXPHOS biogenesis

2023-02-10

Abstract excerpt

Oxidative phosphorylation (OXPHOS) complexes, encoded by both mitochondrial and nuclear DNA, are essential producers of cellular ATP, but how nuclear and mitochondrial gene expression steps are coordinated to achieve balanced OXPHOS biogenesis remains unresolved. Here, we present a parallel quantitative analysis of the human nuclear and mitochondrial messenger RNA (mt-mRNA) life cycles, including transcript produc...

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Literature Corpus work: 00d23a70-d03a-50af-bcc9-8ffa2bec72e8
DOI: 10.1101/2023.02.09.527880

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