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Article

Landscape of the complete RNA chemical modifications in the human 80S ribosome.

Nucleic acids research - 12 Oct 2018

Taoka Masato, Nobe Yuko, Yamaki Yuka, Sato Ko, Ishikawa Hideaki, Izumikawa Keiichi, Yamauchi Yoshio, Hirota Kouji, Nakayama Hiroshi, Takahashi Nobuhiro, Isobe Toshiaki

Abstract excerpt

During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that ensure the fidelity of translation, and dysregulation of the modification processes can cause proteome changes as observed in cancer and inherited human disorders. Here, we report the complete chemical modifications of all RNAs of the human 80S ribosome as determined with quantitative mass spectrometry. We assigned 228 sites...

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Identifiers

PMID: 30202881
DOI: 10.1093/nar/gky811
PMCID: PMC6182160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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