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Article

Multi-site DMS probing reveals higher-order structure of RNA-protein complexes in living cells.

Molecular cell - 7 May 2026

Saleem Irfana, Miller Thomas, Kearns Lucas, Hoang Anthony, Meehan Joshua, Bose Ritwika, Mitchell David, Price David H, Olson Calla M, Weidmann Chase A, Mustoe Anthony M

Abstract excerpt

Identifying tertiary structures and protein binding sites in RNA molecules remains a key challenge in RNA biology. We describe multi-site dimethyl sulfate (DMS)-mutational profiling (MaP) (msDMS-MaP), a strategy that enables simultaneous measurement of RNA secondary, tertiary, and quaternary structures via a single DMS chemical probing experiment. Optimized reverse transcription decodes typically invisible DMS...

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Identifiers

PMID: 42019497
DOI: 10.1016/j.molcel.2026.03.029
PMCID: PMC13120737

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