Article

The human mitochondrial mRNA structurome reveals mechanisms of gene expression

2023-11-02

Abstract excerpt

<h4>Summary</h4> The mammalian mitochondrial genome encodes thirteen oxidative phosphorylation system proteins, crucial in aerobic energy transduction. These proteins are translated from 9 monocistronic and 2 bicistronic transcripts, whose native structures remain unexplored, leaving fundamental molecular determinants of mitochondrial gene expression unknown. To address this gap, we developed a mitoDMS-MaPseq app...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 234053d0-aa62-5a29-9e36-6aa51113559e
DOI: 10.1101/2023.10.31.564750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The human mitochondrial mRNA structurome reveals mechanisms of gene expressionDOI 10.1101/2023.10.31.564750Read

The human mitochondrial mRNA structurome reveals mechanisms of gene expression.Semantic proximity Read

A kinetic dichotomy between mitochondrial and nuclear gene expression drives OXPHOS biogenesisSemantic proximity Read

Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology.Semantic proximity Read

Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome dataSemantic proximity Read

A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seqSemantic proximity Read

LARP4 Is an RNA-Binding Protein That Binds Nuclear-Encoded Mitochondrial mRNAs To Promote Mitochondrial FunctionSemantic proximity Read

Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexesSemantic proximity Read

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and diseaseSemantic proximity Read

Cooperative Architecture of Mitochondrial Proteome HomeostasisSemantic proximity Read

Ribosome Profiling Reveals a Dichotomy Between Ribosome Occupancy of Nuclear-Encoded and Mitochondrial-Encoded OXPHOS mRNA Transcripts in a Striatal Cell Model of Huntington DiseaseSemantic proximity Read

A spatial atlas of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stressSemantic proximity Read

High-resolution genomic analysis of human mitochondrial RNA sequence variation.Semantic proximity Read