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Complement C4, C4A and C4a – What they do and how they differ

13 Jun 2024

Abstract excerpt

Schizophrenia has been linked to the immune system, in particular the major histocompatibility complex class III (MHC), variations in complement component 4 (C4), and a risk association with increased expression of the C4A isotype (Sekar et al., 2016). While the functional role of the C4A protein in pathophysiology remains largely unknown, a more recent study showed that overexpression of C4A promotes excessive...

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PMID: 38988452
DOI: 10.1016/j.bbih.2024.100809

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