Article

Complement component 4 genes contribute sex-specific vulnerability in diverse illnesses

2019-09-09

Abstract excerpt

Many common illnesses differentially affect men and women for unknown reasons. The autoimmune diseases lupus and Sjögren’s syndrome affect nine times more women than men 1,2 , whereas schizophrenia affects men more frequently and severely 3–5 . All three illnesses have their strongest common-genetic associations in the Major Histocompatibility Complex (MHC) locus, an association that in lupus and Sjögren’s syndr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4da48416-65e8-591b-a6e0-53e00a0ba92c
DOI: 10.1101/761718

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Complement component 4 genes contribute sex-specific vulnerability in diverse illnessesDOI 10.1101/761718Read

Complement genes contribute sex-biased vulnerability in diverse disorders.Semantic proximity Read

Schizophrenia risk from complex variation of complement component 4.Semantic proximity Read

The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disordersSemantic proximity Read

The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disordersSemantic proximity Read

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophreniaSemantic proximity Read

Genetic Evidence for a Neuroimmune Model of Schizophrenia.Semantic proximity Read

Analysis of the complement component C4 gene with schizophrenia subphenotypes.Semantic proximity Read

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.Semantic proximity Read

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.Semantic proximity Read

Complement C4, C4A and C4a – What they do and how they differSemantic proximity Read

Peripheral Complement C4 Protein in Schizophrenia: Association with Gene Copy Number and Immune Cell SubtypesSemantic proximity Read

Cross-disorder analysis of schizophrenia and 19 immune diseases reveals genetic correlationSemantic proximity Read