Article
Complement genes contribute sex-biased vulnerability in diverse disorders.
Nature - 1 Jun 2020
Kamitaki Nolan, Sekar Aswin, Handsaker Robert E, de Rivera Heather, Tooley Katherine, Morris David L, Taylor Kimberly E, Whelan Christopher W, Tombleson Philip, Loohuis Loes M Olde, Boehnke Michael, Kimberly Robert P, Kaufman Kenneth M, Harley John B, Langefeld Carl D, Seidman Christine E, Pato Michele T, Pato Carlos N, Ophoff Roel A, Graham Robert R, Criswell Lindsey A, Vyse Timothy J, McCarroll Steven A
Abstract excerpt
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren's syndrome affect nine times more women than men1, whereas schizophrenia affects men with greater frequency and severity relative to women2. All three illnesses have their strongest common genetic associations in the major...
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