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Imputation-Based HLA Typing with GWAS SNPs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Zheng Xiuwen, Lee John

Abstract excerpt

SNP-based imputation approaches for human leukocyte antigen (HLA) typing take advantage of the haplotype structure within the major histocompatibility complex (MHC) region. These methods predict HLA classical alleles using dense SNP genotypes, commonly found on array-based platforms used in genome-wide association studies (GWAS). The analysis of HLA classical alleles can be conducted on current SNP datasets at no...

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PMID: 38907895
DOI: 10.1007/978-1-0716-3874-3_9

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