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Article

HLA type inference via haplotypes identical by descent.

Journal of computational biology : a journal of computational molecular cell biology - 1 Mar 2011

Setty Manu N, Gusev Alexander, Pe'er Itsik

Abstract excerpt

The human leukocyte antigen (HLA) genes play a major role in adaptive immune response and are used to differentiate self antigens from non-self ones. HLA genes are hypervariable with nearly every locus harboring over a dozen alleles. This variation plays an important role in susceptibility to multiple autoimmune diseases and needs to be matched on for organ transplantation. Unfortunately, HLA typing by...

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Identifiers

PMID: 21385049
DOI: 10.1089/cmb.2010.0258

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