Article
Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, -DQB1, and -DPB1.
BMC genetics - 16 Jun 2014
Levin Albert M, Adrianto Indra, Datta Indrani, Iannuzzi Michael C, Trudeau Sheri, McKeigue Paul, Montgomery Courtney G, Rybicki Benjamin A
Abstract excerpt
BACKGROUND: The expense of human leukocyte antigen (HLA) allele genotyping has motivated the development of imputation methods that use dense single nucleotide polymorphism (SNP) genotype data and the region's haplotype structure, but the performance of these methods in admixed populations (such as African Americans) has not been adequately evaluated. We compared genotype-based-derived from both genome-wide...
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