Article

Practical Use of Methods for Imputation of HLA Alleles from SNP Genotype Data

2016-12-09

Abstract excerpt

The human leukocyte antigen (HLA) genes play an essential role in immune function. Typing of HLA alleles is critical for transplantation and is informative for many disease associations. The high cost of accurate lab-based HLA typing has precluded its use in large-scale disease-association studies. The development of statistical methods to type alleles using linkage disequilibrium with nearby SNPs, called HLA impu...

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Literature Corpus work: 55890bc0-6d4b-551c-85c2-44acf08540b0
DOI: 10.1101/091009

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