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Article

Double CYP11B1/CYP11B2 Immunohistochemistry and Detection of KCNJ5 Mutations in Primary Aldosteronism.

The Journal of clinical endocrinology and metabolism - 16 Sept 2024

Caroccia Brasilina, Lenzini Livia, Ceolotto Giulio, Gioco Francesca, Benetti Andrea, Giannella Alessandra, Ajjour Hala, Galuppini Francesca, Pennelli Gianmaria, Seccia Teresa Maria, Gomez-Sanchez Celso, Rossi Gian Paolo

Abstract excerpt

CONTEXT: The search for somatic mutations in adrenals resected from patients with primary aldosteronism (PA) is performed by Sanger sequencing, often implemented with immunohistochemistry (IHC)-guidance focused on aldosterone-producing (CYP11B2-positive) areas. OBJECTIVE: To investigate the impact of double IHC for CYP11B1 and CYP11B2 on Sanger and next-generation sequencing (NGS). METHODS: We investigated 127...

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Share to Adrenal Cortex Neoplasms
Share to Adrenocortical Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP11B2

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to High-Throughput Nucleotide Sequencing

Share to Hyperaldosteronism

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Share to Steroid 11-beta-Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 38888173
DOI: 10.1210/clinem/dgae411
PMCID: PMC11918620

Genes

CYP11B2
CYP11B1
KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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