Article
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2020
De Sousa Kelly, Boulkroun Sheerazed, Baron Stéphanie, Nanba Kazutaka, Wack Maxime, Rainey William E, Rocha Angélique, Giscos-Douriez Isabelle, Meatchi Tchao, Amar Laurence, Travers Simon, Fernandes-Rosa Fabio L, Zennaro Maria-Christina
Abstract excerpt
Aldosterone-producing adenoma (APA) cause primary aldosteronism-the most frequent form of secondary hypertension. Somatic mutations in genes coding for ion channels and ATPases are found in APA and in aldosterone-producing cell clusters. We investigated the genetic, cellular, and molecular heterogeneity of different aldosterone-producing structures in adrenals with APA, to get insight into the mechanisms driving...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.