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Article

Somatic Drivers in Aldosterone-producing Adenomas and Nodules: Insights from a Brazilian Cohort of Primary Aldosteronism.

The Journal of clinical endocrinology and metabolism - 19 May 2026

Guimaraes Augusto G, Goldbaum Tatiana S, Ledesma Felipe L, Freitas-Castro Felipe, Santana Lucas S, Sobrinho Jose Antonio B L, Rossetti Lucas B, Okubo Jessica, Kawahara Eduardo Z, Bortolotto Luiz A, Srougi Victor, Tanno Fabio Y, Nahas Williams C, Chambo Jose L, Pereira Maria Adelaide A, Pio-Abreu Andrea, Silva Giovanio V, Drager Luciano F, Fragoso Maria Candida B V, Latronico Ana Claudia, Mendonca Berenice B, Zerbini Maria Claudia N, Almeida Madson Q

Abstract excerpt

BACKGROUND: The Brazilian population represents a mosaic of genetic diversity resulting from admixture ancestries. Given reported disparities in primary aldosteronism (PA) genetics across ethnicities, we investigated the genetic spectrum of aldosterone-producing adenomas (APAs) and nodules (APNs) with classical histology in a Brazilian cohort. METHODS: We included 62 lesions (1 case with bilateral APAs) from 61...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adrenocortical Adenoma

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Share to Calcium Channels, L-Type

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

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Source

Identifiers

PMID: 41498208
DOI: 10.1210/clinem/dgag002

Genes

ATP2B3
CACNA1D
KCNJ5
ATP1A1
CTNNB1
CYP11B2
CACNA1H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Somatic Drivers in Aldosterone-producing Adenomas and Nodules: Insights from a Brazilian Cohort of Primary Aldosteronism.PMID 41498208Read ↗

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