Article
Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2012
Boulkroun Sheerazed, Beuschlein Felix, Rossi Gian-Paolo, Golib-Dzib José-Felipe, Fischer Evelyn, Amar Laurence, Mulatero Paolo, Samson-Couterie Benoit, Hahner Stefanie, Quinkler Marcus, Fallo Francesco, Letizia Claudio, Allolio Bruno, Ceolotto Giulio, Cicala Maria Verena, Lang Katharina, Lefebvre Hervé, Lenzini Livia, Maniero Carmela, Monticone Silvia, Perrocheau Maelle, Pilon Catia, Plouin Pierre-François, Rayes Nada, Seccia Teresa M, Veglio Franco, Williams Tracy Ann, Zinnamosca Laura, Mantero Franco, Benecke Arndt, Jeunemaitre Xavier, Reincke Martin, Zennaro Maria-Christina
Abstract excerpt
Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene have been described recently in aldosterone-producing adenomas (APAs). The aim of this study was to investigate the prevalence of KCNJ5 mutations in unselected patients with primary aldosteronism and their clinical, biological and molecular correlates. KCNJ5 sequencing was performed on somatic (APA, n=380) and...
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