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Article

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans.

The Journal of clinical endocrinology and metabolism - 1 Oct 2018

Nanba Kazutaka, Omata Kei, Else Tobias, Beck Peter C C, Nanba Aya T, Turcu Adina F, Miller Barbra S, Giordano Thomas J, Tomlins Scott A, Rainey William E

Abstract excerpt

Context: Somatic mutations have been identified in more than half of aldosterone-producing adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of inappropriate aldosterone synthesis in the remaining population is still unknown. Objective: To investigate the prevalence and spectrum of somatic mutations in APAs using an aldosterone synthase (CYP11B2) immunohistochemistry (IHC)‒guided...

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Source

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Identifiers

PMID: 30085035
DOI: 10.1210/jc.2018-01004
PMCID: PMC6179168

Genes

KCNJ5
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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