Article
Increased Frequency and Distinct Genotypic Patterns of Somatic Aldosterone-Driver Mutations in Aldosterone-Producing Micronodules from Primary Aldosteronism Patients.
Endocrine pathology - 20 Mar 2026
Lim Jung Soo, Wu Chun-Yi, Qin Zhaoping, Liu Chia-Jen, van Rooyen Desmaré, Sapiro Dina R, Giordano Thomas J, Turcu Adina F, Rainey William E, Udager Aaron M
Abstract excerpt
Primary aldosteronism (PA) is the leading cause of endocrine hypertension. With the development of highly specific human aldosterone synthase (CYP11B2) antibodies for immunohistochemistry (IHC), the presence of microscopic subcapsular foci of CYP11B2-postive cells – now termed aldosterone-producing micronodules (APM) – has been documented in normal and PA adrenal glands, however, there continues to be debate...
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