Article
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
The Journal of clinical endocrinology and metabolism - 1 Mar 2016
Nanba Kazutaka, Chen Andrew X, Omata Kei, Vinco Michelle, Giordano Thomas J, Else Tobias, Hammer Gary D, Tomlins Scott A, Rainey William E
Abstract excerpt
CONTEXT: The use of next-generation sequencing has resulted in the identification of recurrent somatic mutations underlying primary aldosteronism (PA). However, significant gaps remain in our understanding of the relationship between tumor aldosterone synthase (CYP11B2) expression and somatic mutation status. OBJECTIVE: The objective of the study was to investigate tumor CYP11B2 expression and somatic...
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