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Article

Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.

European journal of endocrinology - 1 Aug 2016

Nanba Kazutaka, Omata Kei, Tomlins Scott A, Giordano Thomas J, Hammer Gary D, Rainey William E, Else Tobias

Abstract excerpt

OBJECTIVE: Co-secretion of cortisol and aldosterone can be observed in adrenal adenomas. The aim of this study was to investigate the molecular characteristics of a co-existing aldosterone- and a cortisol-producing adenoma (CPA) in the same patient. DESIGN AND METHODS: Two different adenomas within the same adrenal gland from a 49-year-old female patient with primary aldosteronism (PA) and Cushing's syndrome (CS)...

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Share to Adrenal Cortex Neoplasms
Share to Adrenocortical Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldosterone

Share to Cushing Syndrome

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to Hydrocortisone

Share to Hyperaldosteronism

Share to Neoplasms, Multiple Primary

Source

Open in PubMed Open full text

Identifiers

PMID: 27165862
DOI: 10.1530/EJE-16-0262
PMCID: PMC5030510

Genes

KCNJ5
PRKACA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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