Article
Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.
Nature communications - 7 Aug 2018
Voon Hsiao P J, Udugama Maheshi, Lin Wendi, Hii Linda, Law Ruby H P, Steer David L, Das Partha P, Mann Jeffrey R, Wong Lee H
Abstract excerpt
An array of oncogenic histone point mutations have been identified across a number of different cancer studies. It has been suggested that some of these mutant histones can exert their effects by inhibiting epigenetic writers. Here, we report that the H3.3 G34R (glycine to arginine) substitution mutation, found in paediatric gliomas, causes widespread changes in H3K9me3 and H3K36me3 by interfering with the KDM4...
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