Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer's disease.

doi:10.1016/j.nicl.2024.103626

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Article

Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer's disease.

NeuroImage. Clinical - 1 Jan 2024

Gouilly Dominique, Vrillon Agathe, Bertrand Elsa, Goubeaud Marie, Catala Hélène, Germain Johanne, Ainaoui Nadéra, Rafiq Marie, Nogueira Leonor, Mouton-Liger François, Planton Mélanie, Salabert Anne-Sophie, Hitzel Anne, Méligne Déborah, Jasse Laurence, Sarton Benjamine, Silva Stein, Lemesle Béatrice, Péran Patrice, Payoux Pierre, Thalamas Claire, Paquet Claire, Pariente Jérémie

Abstract excerpt

BACKGROUND: PET imaging of the translocator protein (TSPO) is used to assess in vivo brain inflammation. One of the main methodological issues with this method is the allelic dependence of the radiotracer affinity. In Alzheimer's disease (AD), previous studies have shown similar clinical and patho-biological profiles between TSPO genetic subgroups. However, there is no evidence regarding the effect of the TSPO...

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Identifiers

PMID: 38850834
DOI: 10.1016/j.nicl.2024.103626
PMCID: PMC11201347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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