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Article

Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 May 2015

Fan Zhen, Harold Denise, Pasqualetti Giuseppe, Williams Julie, Brooks David J, Edison Paul

Abstract excerpt

UNLABELLED: Neuroinflammation plays a significant role in Alzheimer disease (AD), and translocator protein (TSPO) PET imaging allows us to quantify this process. However, the binding of second-generation TSPO tracers depends on the TSPO genotype coded by the rs6971 single-nucleotide polymorphism,...

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Source

Identifiers

PMID: 25840980
DOI: 10.2967/jnumed.114.149443

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25840980-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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