Article
Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jul 2015
Lavisse Sonia, García-Lorenzo Daniel, Peyronneau Marie-Anne, Bodini Benedetta, Thiriez Claire, Kuhnast Bertrand, Comtat Claude, Remy Philippe, Stankoff Bruno, Bottlaender Michel
Abstract excerpt
UNLABELLED: Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood...
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