Article
A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jan 2013
Kreisl William C, Jenko Kimberly J, Hines Christina S, Lyoo Chul Hyoung, Corona Winston, Morse Cheryl L, Zoghbi Sami S, Hyde Thomas, Kleinman Joel E, Pike Victor W, McMahon Francis J, Innis Robert B
Abstract excerpt
Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or heterozygous (HL). We tested if in vitro binding to leukocytes distinguished TSPO genotypes and if genotype could affect clinical...
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