An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.

doi:10.1038/jcbfm.2011.147

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Article

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jan 2012

Owen David R, Yeo Astrid J, Gunn Roger N, Song Kijoung, Wadsworth Graham, Lewis Andrew, Rhodes Chris, Pulford David J, Bennacef Idriss, Parker Christine A, StJean Pamela L, Cardon Lon R, Mooser Vincent E, Matthews Paul M, Rabiner Eugenii A, Rubio Justin P

Abstract excerpt

[(11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain...

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PMID: 22008728
DOI: 10.1038/jcbfm.2011.147
PMCID: PMC3323305

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TSPO

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