Article

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

2022-03-23

Abstract excerpt

<title>Abstract</title> <p>Microglial activation plays central roles in neuro-inflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative interpretation remains uncertain. For the first time, we show that TSPO gene and protein expression increases in activated microglia in mouse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd9eff42-93f7-50d8-9951-1750e8a373c3
DOI: 10.21203/rs.3.rs-1420033/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseasesDOI 10.21203/rs.3.rs-1420033/v1Read

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseasesSemantic proximity Read

The microglial translocator protein (TSPO) in Alzheimer's disease reflects a phagocytic phenotype.Semantic proximity Read

Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical OutcomeSemantic proximity Read

Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer's disease.Semantic proximity Read

Towards PET imaging of the dynamic phenotypes of microgliaSemantic proximity Read

TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s diseaseSemantic proximity Read

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus.Semantic proximity Read

Translocator Protein (18 kDa) Polymorphism (rs6971) Explains <i>in-vivo</i> Brain Binding Affinity of the PET Radioligand [ <sup>18</sup> F]-FEPPASemantic proximity Read

Development and evaluation of [11C]DPA-813 and [18F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971.Semantic proximity Read

Mitochondria drive microglial NRLP3 inflammasome activation via TSPOSemantic proximity Read

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microgliaSemantic proximity Read

In vivo Assessment of Neuroinflammation in 4-Repeat TauopathiesSemantic proximity Read