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Article

Clonal hematopoiesis: Molecular and clinical implications.

Leukemia research - 1 Feb 2022

Kusne Yael, Xie Zhuoer, Patnaik Mrinal M

Abstract excerpt

Clonal hematopoiesis (CH) defines a population of hematopoietic cells with one or more somatic mutations/copy number alterations that can expand with time and under positive clonal selection pressures. The term CH of indeterminate potential (CHIP) operationally describes somatic mutations in leukemia-associated driver genes in hematopoietic stem cells with variant allele frequencies (VAF) of ≥ 2%, without...

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Identifiers

PMID: 35091334
DOI: 10.1016/j.leukres.2022.106787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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