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Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics

24 May 2022

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease. Whole-exome or genome sequencing can detect CHIP, but due to those assays' high cost, most population studies have been cross-sectional, sequencing only a single timepoint per...

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PMID: 35610705
DOI: 10.1186/s12979-022-00278-9

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