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Article

Defining clonal hematopoiesis of indeterminate potential: evolutionary dynamics and detection under aging and inflammation.

Cold Spring Harbor molecular case studies - 1 Apr 2023

Goldman Elisabeth A, Spellman Paul T, Agarwal Anupriya

Abstract excerpt

Clonal hematopoiesis (CH), in which hematopoietic stem and progenitor cell (HSPC) clones and their progeny expand in the circulating blood cell population, occurs following the acquisition of somatic driver mutations. Individuals diagnosed with clonal hematopoiesis of indeterminate potential (CHIP) carry somatic mutations in hematological malignancy-associated driver genes, historically at or above a variant...

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Identifiers

PMID: 36889927
DOI: 10.1101/mcs.a006251
PMCID: PMC10240836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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