Article
Clonal hematopoiesis.
Seminars in hematology - 1 Jan 2017
Jan Max, Ebert Benjamin L, Jaiswal Siddhartha
Abstract excerpt
Cancer results from multistep pathogenesis, yet the pre-malignant states that precede the development of many hematologic malignancies have been difficult to identify. Recent genomic studies of blood DNA from tens of thousands of people have revealed the presence of remarkably common, age-associated somatic mutations in genes associated with hematologic malignancies. These somatic mutations drive the expansion...
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