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Article

Clonal hematopoiesis of indeterminate potential and cardiovascular disease.

Translational research : the journal of laboratory and clinical medicine - 1 May 2023

Saadatagah Seyedmohammad, Ballantyne Christie M

Abstract excerpt

Age is the most important risk factor for cardiovascular disease and appears to be more than a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension. With aging, genetic mutations occur that are not present in our germline DNA, observed as somatic mosaicism. Hematopoietic stem cells have an increased chance of developing mosaicism because they are highly proliferative, and...

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PMID: 36067904
DOI: 10.1016/j.trsl.2022.08.013

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