Article
Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics.
The Journal of molecular diagnostics : JMD - 1 Jul 2024
Mack Taralynn, Vlasschaert Caitlyn, von Beck Kelly, Silver Alexander J, Heimlich J Brett, Poisner Hannah, Condon Henry R, Ulloa Jessica, Sochacki Andrew L, Spaulding Travis P, Kishtagari Ashwin, Bejan Cosmin A, Xu Yaomin, Savona Michael R, Jones Angela, Bick Alexander G
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related phenomenon in which hematopoietic stem cells acquire mutations in a select set of genes commonly mutated in myeloid neoplasia which then expand clonally. Current sequencing assays to detect CHIP mutations are not optimized for the detection of these variants and can be cost-prohibitive when applied to large cohorts or to serial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.