Article
Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma.
Scientific reports - 22 Mar 2017
Jalbert Llewellyn E, Elkhaled Adam, Phillips Joanna J, Neill Evan, Williams Aurelia, Crane Jason C, Olson Marram P, Molinaro Annette M, Berger Mitchel S, Kurhanewicz John, Ronen Sabrina M, Chang Susan M, Nelson Sarah J
Abstract excerpt
Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) oncogenes are more likely to have a favorable outcome and be sensitive to treatment. Because of their relatively long overall median survival, more...
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