Article

Cerebrospinal fluid D-2-hydroxyglutarate for IDH-mutant glioma: utility for detection versus monitoring

2025-04-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Imaging-based monitoring of gliomas is limited by treatment-related changes. D-2-hydroxyglutarate (D-2-HG), produced by the isocitrate dehydrogenase (IDH) mutation, is detectable in cerebrospinal fluid (CSF) that can be accessed from various anatomic compartments. We evaluated CSF D-2-HG as a serially accessible biomarker for IDH-mutant gliomas. <h4>METHODS</h4> A CLIA-approve...

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Literature Corpus work: 28213ece-9d30-5739-860b-77a9e35c3ee8
DOI: 10.1101/2025.04.08.25325500

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