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Article

Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription.

Cell - 23 May 2024

Yu Yingpu, Kass Maximilian A, Zhang Mengyin, Youssef Noor, Freije Catherine A, Brock Kelly P, Aguado Lauren C, Seifert Leon L, Venkittu Sanjana, Hong Xupeng, Shlomai Amir, de Jong Ype P, Marks Debora S, Rice Charles M, Schneider William M

Abstract excerpt

Hepatitis B virus (HBV) is a small double-stranded DNA virus that chronically infects 296 million people. Over half of its compact genome encodes proteins in two overlapping reading frames, and during evolution, multiple selective pressures can act on shared nucleotides. This study combines an RNA-based HBV cell culture system with deep mutational scanning (DMS) to uncouple cis- and trans-acting sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38723628
DOI: 10.1016/j.cell.2024.04.008
PMCID: PMC11127778

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