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Article

Virus attenuation by genome-scale changes in codon pair bias.

Science (New York, N.Y.) - 27 Jun 2008

Coleman J Robert, Papamichail Dimitris, Skiena Steven, Futcher Bruce, Wimmer Eckard, Mueller Steffen

Abstract excerpt

As a result of the redundancy of the genetic code, adjacent pairs of amino acids can be encoded by as many as 36 different pairs of synonymous codons. A species-specific "codon pair bias" provides that some synonymous codon pairs are used more or less frequently than statistically predicted. We synthesized de novo large DNA molecules using hundreds of over-or underrepresented synonymous codon pairs to encode the...

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Identifiers

PMID: 18583614
DOI: 10.1126/science.1155761
PMCID: PMC2754401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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