Article

Predicted structure of the hepatitis B virus polymerase reveals an ancient conserved protein fold

2022-02-17

Abstract excerpt

Hepatitis B virus (HBV) replicates by protein-primed reverse transcription. It chronically infects >250 million people, and the dominant anti-HBV drugs are nucleos(t)ide analogs targeting the viral polymerase (P). P has four domains, the terminal protein (TP) that primes DNA synthesis, a spacer, the reverse transcriptase (RT), and the ribonuclease H (RNaseH). Despite being a major drug target and catalyzing a reve...

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Literature Corpus work: f83f5d03-b26e-5a51-be63-6041d3bf1f07
DOI: 10.1101/2022.02.16.480762

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