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Article

Scanning the horizon: deep mutational scanning approaches in virology.

Journal of virology - 21 Jul 2026

Dorman Jack, Bakhache William, Dolan Patrick T

Abstract excerpt

Studying the effects of mutations is central to virology. Deep mutational scanning (DMS) is a technique that couples high-throughput mutagenesis with deep sequencing to measure the effects of mutations in pooled assays. When adapted to viruses, DMS accelerates comprehensive measurement of mutational effects across viral genomes, mapping evolutionary constraints on viral proteins. Recently, DMS has been applied to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42267826
DOI: 10.1128/jvi.01784-25
PMCID: PMC13386985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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