Article

Comparative Analysis of Deep Mutational Scanning Datasets in Enteroviruses A and B Identifies Functional Divergence and Therapeutic Targets

2025-09-08

Abstract excerpt

<title>Abstract</title> <p>Deep mutational scanning (DMS) can define functional constraints acting on viral proteomes by quantifying the effects of mutations on viral fitness. However, DMS analyses do not discern type-specific from species-level constraints, limiting their utility in understanding how selective pressures change as viral families diversify. Here, we show that comparison of DMS datasets from relate...

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Literature Corpus work: 5a82ca1b-8723-52bb-b570-9b7da1986de1
DOI: 10.21203/rs.3.rs-7483105/v1

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