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Article

Structural adaptations for enhanced translation kinetics in evolved ribosomes.

Nucleic acids research - 17 Jul 2026

Raskar Tushar, Costello Alan, Badran Ahmed H, Fraser James S

Abstract excerpt

The ribosomal RNA sequence governs translation dynamics, yet understanding how changes beyond the conserved catalytic centers influence kinetics and protein yield remains limited. Using orthogonal ribosome phage-assisted continuous evolution, we recently reported chimeric ribosomes derived from Escherichia coli, Pseudomonas aeruginosa, and Vibrio cholerae endowed with elevated orthogonal translation activity as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42483832
DOI: 10.1093/nar/gkag703
PMCID: PMC13389312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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