Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-throughput interrogation of programmed ribosomal frameshifting in human cells.

Nature communications - 16 Jun 2020

Mikl Martin, Pilpel Yitzhak, Segal Eran

Abstract excerpt

Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human viruses such as HIV and SARS coronavirus and is critical for their replication. Here, we developed a high-throughput approach to assess the frameshifting potential of a sequence. We designed and tested >12,000 sequences based on 15 viral and human PRF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frameshifting, Ribosomal
Share to Green Fluorescent Proteins
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to K562 Cells

Share to Luminescent Proteins

Share to Protein Biosynthesis

Share to Red Fluorescent Protein

Share to RNA, Transfer

Source

Open in PubMed Open full text

Identifiers

PMID: 32546731
DOI: 10.1038/s41467-020-16961-8
PMCID: PMC7297798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-throughput interrogation of programmed ribosomal frameshifting in human cells.PMID 32546731Read ↗

High-throughput interrogation of programmed ribosomal frameshifting in human cellsSemantic proximity Read ↗

The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed –1 ribosomal frameshiftingSemantic proximity Read ↗

A Statistical Detector for Ribosomal Frameshifts and Dual Encodings based on Ribosome ProfilingSemantic proximity Read ↗

A Computational and Biochemical Study of -1 Ribosomal Frameshifting in Human mRNAsSemantic proximity Read ↗

Biological Significance and Therapeutic Promise of Programmed Ribosomal FrameshiftingSemantic proximity Read ↗

Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal FrameshiftingSemantic proximity Read ↗

Programmed ribosomal frameshifting in HIV-1 and the SARS–CoVSemantic proximity Read ↗

Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target.Semantic proximity Read ↗

Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cellsSemantic proximity Read ↗

RNA elements required for the high efficiency of West Nile Virus-induced ribosomal frameshiftingSemantic proximity Read ↗

A review on architecture of the gag-pol ribosomal frameshifting RNA in human immunodeficiency virus: a variability survey of virus genotypes.Semantic proximity Read ↗

The human immunodeficiency virus type 1 ribosomal frameshifting site is an invariant sequence determinant and an important target for antiviral therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.