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Article

Improving virus production through quasispecies genomic selection and molecular breeding.

Scientific reports - 3 Nov 2016

Pérez-Rodríguez Francisco J, D'Andrea Lucía, de Castellarnau Montserrat, Costafreda Maria Isabel, Guix Susana, Ribes Enric, Quer Josep, Gregori Josep, Bosch Albert, Pintó Rosa M

Abstract excerpt

Virus production still is a challenging issue in antigen manufacture, particularly with slow-growing viruses. Deep-sequencing of genomic regions indicative of efficient replication may be used to identify high-fitness minority individuals suppressed by the ensemble of mutants in a virus quasispecies. Molecular breeding of quasispecies containing colonizer individuals, under regimes allowing more than one...

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Identifiers

PMID: 27808108
DOI: 10.1038/srep35962
PMCID: PMC5093897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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