Comparative analysis of deep mutational scanning datasets in enteroviruses A and B identifies functional divergence and therapeutic targets.

Abstract excerpt

Deep mutational scanning (DMS) can define functional constraints acting on viral proteomes by quantifying the effects of mutations on viral fitness. However, DMS analyses do not discern type-specific from species-level constraints, limiting their utility in understanding how selective pressures change as viral families diversify. Here we show that comparison of DMS datasets from related viruses can overcome these...

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