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Article

The Critical Role of Codon Composition on the Translation Efficiency Robustness of the Hepatitis A Virus Capsid

8 Jul 2019

Abstract excerpt

Hepatoviruses show an intriguing deviated codon usage, suggesting an evolutionary signature. Abundant and rare codons in the cellular genome are scarce in the human hepatitis A virus (HAV) genome, while intermediately abundant host codons are abundant in the virus. Genotype-phenotype maps, or fitness landscapes, are a means of representing a genotype position in sequence space and uncovering how genotype relates...

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PMID: 31290967
DOI: 10.1093/gbe/evz146

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