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Article

Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning.

Nucleic acids research - 16 Dec 2021

Carmody Patrick J, Zimmer Matthew H, Kuntz Charles P, Harrington Haley R, Duckworth Kate E, Penn Wesley D, Mukhopadhyay Suchetana, Miller Thomas F, Schlebach Jonathan P

Abstract excerpt

Programmed ribosomal frameshifting (PRF) is a translational recoding mechanism that enables the synthesis of multiple polypeptides from a single transcript. During translation of the alphavirus structural polyprotein, the efficiency of -1PRF is coordinated by a 'slippery' sequence in the transcript, an adjacent RNA stem-loop, and a conformational transition in the nascent polypeptide chain. To characterize each...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34871407
DOI: 10.1093/nar/gkab1172
PMCID: PMC8682741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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