Article

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes

2025-09-09

Abstract excerpt

Current single-cell multiomics methods typically provide limited genomic information, constraining genotype-phenotype studies. To address this gap, we developed SPLONGGET (Single-cell Profiling of LONG-read Genome, Epigenome, and Transcriptome), which integrates 10X Genomics barcoding with Oxford Nanopore sequencing to simultaneously profile genome, chromatin accessibility, and full-length transcriptomes in thousa...

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Literature Corpus work: d8e0db96-3eb1-5487-8872-d1672c7204be
DOI: 10.1101/2025.09.08.674950

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