Article

Histone H2AK119 Mono-Ubiquitination is Essential for Polycomb-Mediated Transcriptional Repression

2019-07-02

Abstract excerpt

<h4>ABSTRACT</h4> The major function of Polycomb group proteins (PcG) is to maintain transcriptional repression to preserve cellular identity. This is exerted by two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27me3, respectively. Both complexes are essential for development and are deregulated in several types of human tumors. PRC1 and PRC2 exist in differen...

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Literature Corpus work: d7cc5d5e-8536-5be1-b1b8-c21219b927b3
DOI: 10.1101/690461

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